ESR1 and neoplasm: In all familial cancers a higher VEGF expression was significantly associated to poor tumor grade (p = 0.0074), ER, PR negative (p = 0.0206 and p = 0.0002 respectively), and MIB-1 positive (p = 0.0044); whereas in the sporadic group VEGF positive expression was significantly associated only with ER negative status (p = 0.0296).