Moreover, the percentage of HIF-1α expression was significantly higher in the BRCA1-2 carriers (median value 15%, range 0–70) than in BRCAX cancers (median value 3%, range 0–64) (p<0.05), and in the sporadic group (median value 0%, range 0–60) (p = 0.0002). Here, HIF1A is linked to cancer.