ACTA (alpha skeletal muscle actin), MYH2 (myosin, heavy chain 2, skeletal muscle, adult), TNNT1 (troponin T, slow skeletal muscle), ACTN2 (alpha-actinin skeletal muscle), TRIM63 (muscle-specific ring finger protein) and RYR1 (Skeletal muscle calcium release channel) were present among the 1,126 genes that were overexpressed in both miPS and myoblasts versus fibroblasts, exhibiting a high score of muscle phenotype and muscle GO-terms such as muscle contraction, muscle filament sliding, structural constituents of muscle, myogenesis and myopathy (see list in Table 1). The gene discussed is ACTN2; the disease is myopathy.