From a pathophysiological point of view, it is remarkable that a model derived from a cohort primarily consisting of PKD1 patients (although not genotyped, most patients of the SUISSE ADPKD study are expected to have the PKD1 genotype) still positively diagnosed most (77.4%) of the PKD2 patients. This evidence concerns the gene PKD2 and autosomal dominant polycystic kidney disease.