More recently, the effects of the GnRH agonistic analogue leuprorelin acetate (LA) on the expression of GnRH-R were investigated by Western blotting in two human PCa cell lines: the androgen-sensitive, well-differentiated and low invasive LNCaP cells and the androgen-insensitive, poorly differentiated and highly invasive PC-3 cells [24]. Here, GNRH1 is linked to posterior cortical atrophy.