Familial Hemiplegic Migraine type 1 (FHM-1) is a rare monogenic subtype of migraine caused by missense mutations in the CACNA1A gene, which encodes the α1 subunit of CaV2.1 (P/Q-type) Ca2+ channels [1], [2]. The gene discussed is CACNA1A; the disease is migraine, familial hemiplegic, 1.