Familial Hemiplegic Migraine type 1 (FHM-1) is a rare monogenic subtype of migraine caused by missense mutations in the CACNA1A gene, which encodes the α1 subunit of CaV2.1 (P/Q-type) Ca2+ channels [1], [2]. This evidence concerns the gene CACNA1A and familial or sporadic hemiplegic migraine.