Although the specific mechanism by which SATB1 affects the biologic behavior of CRC are unknown, studies of T cell development and breast cancer suggest that SATB1 functions in a global manner via chromatin remodeling and transactivation of the transcription factors of hundreds of gene associated with various signaling pathways, such as the growth factor, Wnt/β-catenin and NF-κB pathways which are known to be crucial in CRC development [7], [16] as well as via DNA repair and genetic mutation which are initiating factors in CRC tumourgenesis [22], [37]. Here, NFKB1 is linked to breast cancer.