In its role as an important protein in chromatin reorganization, SATB1 can up-regulate expression of PARP1 which takes part in single-stranded DNA repair resulting in synthetic lethality in BRCA1/2 defective cancers.PARP1 inhibitors have been successfully applied in clinical treatment for breast and ovarian cancers [28], [29]. The gene discussed is BRCA1; the disease is cancer.