NOS2 and neoplasm: NF-κB regulates the expression of several genes, such as cyclooxygenase- (COX-) 2, inducible nitric oxide synthase (iNOS), tumor necrosis factor (TNF-) α, interleukin (IL-) 1β, cell surface adhesion molecules, and antiapoptotic proteins, which are involved in tumor initiation, promotion, and metastasis [43].