Interestingly, in a recent study by Ticozzi et al. [12], CSF was collected from 259 patients with ALS, screened also for mutations of SOD1, FUS, TARDBP, angiogenin (ANG), optineurin (OPTN), and C9ORF72 genes. Here, C9orf72 is linked to amyotrophic lateral sclerosis.