Interestingly, in a recent study by Ticozzi et al. [12], CSF was collected from 259 patients with ALS, screened also for mutations of SOD1, FUS, TARDBP, angiogenin (ANG), optineurin (OPTN), and C9ORF72 genes. This evidence concerns the gene SOD1 and amyotrophic lateral sclerosis.