We screened genetic susceptibility to motor neuron disorders by testing some genes linked to similar phenotypes of ALS in the Italian population: we did not found any mutation of superoxide dismutase 1 (SOD1), transactive response-DNA binding protein (TARDBP), fusion in malignant liposarcoma/translocated in liposarcoma (FUS/TLS) and C9ORF72 genes. The gene discussed is TARDBP; the disease is amyotrophic lateral sclerosis.