In order to investigate whether priming of antigen-specific T cells in the dLN in response to influenza infection was altered in C3−/− mice, we adoptively transferred CFSE labeled OT-I CD8+ transgenic T cells into mice prior to infection with either wild type PR8 influenza virus or recombinant PR8 influenza virus containing the OVA epitope SIINFEKL (PR8-OT-I). This evidence concerns the gene CD8A and influenza.