Our finding that high passage LNCaP prostate cancer cells (androgen independent) have increased levels of the enzyme FucTH (FUT1 gene) responsible for α1, 2-fucosylation and the H (II) and Ley epitopes with respect to low passage LNCaP cells may represent a potential marker of higher malignancy or androgen refractory prostate cancer cells and may be relevant in diagnosing prostate cancer stage. This evidence concerns the gene FUT1 and prostate cancer.