IL10 and Insulin resistance: The anti-inflammatory cytokine interleukin-10 (IL-10) [21] and Twist-1, a basic helix-loop-helix transcription factor whose expression in human white adipose tissue is inversely correlated with inflammation and insulin resistance [22], are also increased in high-fat diet-fed ad-12/15-LO mice compared to wild type mice (Figure 3(b)).