CD8A and type 1 diabetes mellitus: For example, it has been shown that the infection of nonobese diabetic (NOD) mice with Heligmosomoides polygyrus has a protective effect in T1D, resulting in the regulation of hyperglycemia and reduced incidence of diabetes; these effects were accompanied by reduced numbers of macrophages, dendritic cells, and CD4+ and CD8+ T cells in the inflammatory infiltrate in the pancreas, as well as a reduction on β cell damage.