During obesity, lipid accumulation causes a high degree of stress on adipocytes, activating them and promoting the production and subsequent release of free fatty acids (FFA), proinflammatory adipocytokines (such as leptin and resistin), and cytokines, such as IL-1β, IL-6, TNF-α, MCP-1, and MIF, as well as ROS [61–63], ensuring that in addition to its well-known capacity to store energy, AT has the capability to function as an endocrine organ. Here, CCL2 is linked to obesity due to melanocortin 4 receptor deficiency.