TNF-α (one of the cytokines most abundantly secreted by CAMφs) has the ability to reduce the expression of important genes in the glucose regulation process, such as the glucose transporter GLUT-4 [4]; in fact, TNF-α receptor knock out mice are resistant to diabetes induction [69], suggesting that the endocrine function of AT is important in the recruitment and activation of CAMφs and the induction of insulin resistance. The gene discussed is TNF; the disease is Insulin resistance.