Several additional lines of evidence support the notion that TS-miRNAs can target the STAT3 pathway to alleviate immune suppression: (i) let-7a overexpression in hepatoma cells suppressed cell proliferation through STAT3, (ii) miR-17-5p and miR-20a abrogated the immune-suppressive effects of MDSCs in vivo through the regulation of STAT3 and (iii) miR-93 inhibited tumor development and metastasis in mouse xenografts, at least in part by attenuating the TGF-β and/or STAT3 pathways [100–102]. This evidence concerns the gene STAT3 and hepatocellular carcinoma.