In breast cancer cells, miR-340 suppressed tumor cell migration and invasion by lowering the abundance of c-Met, a factor that promotes expression of MMP-2 and MMP-9; MMP-2 was additionally repressed by miR-29b in HCC cells, attenuating HCC cell invasiveness and angiogenic activity [81,82]. This evidence concerns the gene MMP9 and hepatocellular carcinoma.