CREBBP and neoplasm: However, the tumor/normal log2 ratios (Figure 2) of AXIN1, CREBBP, GSK3A, and NKD2 in the BRAF wildtype samples were low (−0.26 median, 0.12 standard deviation) compared with those in the BRAF mutated samples (−0.02 median, 0.12 standard deviation).