Among the four genes enriched in this pathway were the FOX transcription factors FOXD3, FOXB1, and FOXB2. A recent study described FOXD3 as a TP53 and CDKN1A/p21cip1-dependent negative cell cycle regulator, which is suppressed by activated BRAF in melanoma cells [26]. The gene discussed is FOXB1; the disease is melanoma.