An in vitro study showed that blockade of the CXCR4/CXCL12 axis by transfection with a CXCR4 antisense nucleotide fragment or by a CXCR4 neutralizing antibody significantly decreases migration, invasion, and adhesion of NSCLC cell line cells [67]. The gene discussed is CXCL12; the disease is non-small cell lung carcinoma.