Up-regulated miR-125a significantly inhibits the malignant phenotypes by repressing the expression of matrix metalloproteinase 11 (MMP11) and vascular endothelial growth factor A (VEGF-A) both in vitro and in vivo [12], while the direct targets of miR-125b in miRNA-induced inhibition of hepatocellular carcinoma cell proliferation are Mcl-1 and IL6R [25]. Here, MMP11 is linked to hepatocellular carcinoma.