IL2 and hereditary clear cell renal cell carcinoma: However, a previous study that evaluated recombinant IL2 (rIL2) and low-dose cyclophosphamide in patients with malignant melanoma and renal cell carcinoma reported that the regimen had minimal anti-tumor activity—no remission in renal cell carcinoma patients and partial or minor response in 3 (17%) melanoma patients [26].