A variety of approaches have been investigated to therapeutically target EpCAM-expressing tumors, including anti-EpCAM scFv–Pseudomonas exotoxin A fusion construct evaluation in patients with squamous cell carcinoma of the head and neck [10], vaccination with EpCAM protein to induce EpCAM-specific T-cell responses in patients with colorectal carcinoma [11], and a number of monoclonal, bi-specific and tri-specific anti-EpCAM antibody therapies [12-16]. The gene discussed is EPCAM; the disease is colorectal carcinoma.