For most PBMC populations (cytotoxic NK cells, CD4+ T-cells, CD8+ T-cells, and T-reg cells), rebound to values higher than baseline was observed at day 8, with return to baseline or near-baseline values by day 1 of the subsequent cycle, again mirroring the temporal pattern of recovery from lymphopenia (Figure 4). The gene discussed is CD8A; the disease is lymphopenia.