To our current knowledge, we are the first in the literature demonstrating cardiac gene expression changes of a novel epithelial extracellular matrix component[91], similar to collagen type XXIV; a cell migration regulator molecule[92], myosin IXA; a membrane stabilizer molecule[93], spectrin beta 3 and an extracellular matrix component proteoglycan[94], aggrecan 1, due to metabolic syndrome. The gene discussed is ACAN; the disease is metabolic syndrome.