A recent study on post-mortem brain tissue from patients with MS indicates that TWEAK is increased in meningeal macrophages, in astrocytes, and in microglia associated with lesions and vascular abnormalities, and that Fn14 is mainly localized in neurons and reactive astrocytes of the cerebral cortex in highly infiltrated MS brains [21]. Here, TNFRSF12A is linked to myeloid sarcoma.