Tregs secrete transforming growth factor-beta (TGF-β) and interleukin-10 (IL-10), which down-regulate antitumour immunity, suppressing the antigen presentation by DCs, CD4+ T helper (Th) cell function and the generation of tumour specific CD8+ cytotoxic T lymphocytes (CTLs) [10,15]. This evidence concerns the gene IL10 and neoplasm.