Therefore, additional studies to unravel the properties of H2A.Z/H2B.Z double-variant nucleosomes, identify the chaperone involved in H2B.Z deposition and uncover effector–proteins that specifically recognize this nucleosome subtype will be imperative to explore the potential use of epidrugs targeting H2B.Z-associated pathways in the battle against malaria. This evidence concerns the gene H2BC21 and malaria.