CXCR4 and breast carcinoma: Our previous data have demonstrated that insulin-like growth factor 1 receptor (IGF-1R) can transactivate the chemokine receptor CXCR4 via a physical association between IGF-1R and CXCR4 in human MDA-MB-231 metastatic breast cancer cells and that this plays a key role in IGF-I-induced motility of these cells [2].