Furthermore, MET/HGF plays an important role in cancer development which was attributed through numerous mechanisms such as 1-activation of key oncogenic pathways (RAS, PI3 K, STAT, and β-catenin), 2-angiogenesis, and 3-scatter (cell dissociation due to metalloprotease production) which leads to invasion and metastasis [23]. The gene discussed is HGF; the disease is cancer.