A cross-talk between the RON gene (a member of the receptor tyrosine kinase gene family that includes c-Met oncogene) and c-Met has been identified in ovarian cancer.In a study by Maggiora et al., RON and c-Met oncogenes were coexpressed in 42% of ovarian cancer cases and it has been suggested that this coexpression might cooperate in promoting ovarian cancer progression [50]. The gene discussed is NTRK1; the disease is ovarian carcinoma.