Although literature research has only came up with dry eyes, [8] and recurrent corneal erosions [7] as possible clinical corneal associations of EGFR inhibitors, the authors believe that gefitinib is a plausible cause of corneal perforation and possibly graft melt in this patient based on the drug effect on the EGFR and the clinical findings of a white eye with no sign of infection or inflammation. This evidence concerns the gene EGFR and dry eye syndrome.