VEGFA and Kaposi's sarcoma: Recently, some data suggest that switching to immunosuppressive therapy using a (Sirolimus or Everolimus) can induce the regression of iatrogenic KS through antiangiogenic activity related to impaired VEGF production and the limited proliferative response of endothelial cells to VEGF stimulation [8, 9]; additionally, L. A. Nichols showed a probable role of mTOR inhibitor in the prevention of KS in immunosuppressed patient by blocking HHV-8 production via the regulation of replication and transcription activator expression [14].