Therefore, the identification of lipomatous, myomatous, and angiomatous tissue by a positive reaction to HMB-45 currently provides the only evidence of HAML [4–6, 18] and can be useful for defining from the other liver tumors such as HCC after the tumor biopsy and surgical resection followed by these immunohistochemical stainings. Here, PMEL is linked to hepatocellular carcinoma.