AGTR2 and nervous system disorder: Furthermore, the recent development of selective AT2 receptor agonists should facilitate efforts to elucidate distinct roles of the AT2 receptor in brain physiology, supporting or disproving the hypothesis that the AT2 receptor helps improve a number of brain impairments related to neuronal plasticity and morphology, microcirculation and inflammation (Figure 3), all of which are altered in certain neurological disorders.