When the patients with SE were excluded from the analysis, the DRB1*08∶03 and DQB1*06∶01 allele frequencies were significantly higher in Ro(+)La(−)RA than Ro(−)La(−)RA (Pc = 0.0008, OR 3.33, 95%CI 1.91–5.82, and Pc = 0.0191, OR 2.05, 95%CI 1.33–3.15, respectively, Table 5). Here, HLA-DRB1 is linked to rheumatoid arthritis.