As shown in Figure 5A, the effect of vorinostat (5 μM/8 h) on the expression pattern of genes altered in MDS and/or AML, with the exceptions of STAT2, Gravin and Cyclin D1, mirrored that observed in K562, HL60, and THP1 cell lines: p15, RAI3 and COX2 were significantly up-regulated, IER3 and cFOS moderately up-regulated, c-MYC, AXL and MZF1 suppressed. This evidence concerns the gene IER3 and acute myeloid leukemia.