Specifically, IER3, RAI3, cFOS, COX2, STAT2 and Gravin, frequently suppressed in MDS patients [7], [8], were significantly up-regulated by vorinostat in both cell lines (Figure 4A, 1 and 2), whereas c-MYC, a major player in haematopoiesis and often deregulated in many haematological disorders [39], and MZF1, involved in oncogenesis progression [38], were significantly down-regulated (Figure 4A, 1 and 3). This evidence concerns the gene AKAP12 and hematologic disorder.