CCND1 and acute myeloid leukemia: Interestingly, some genes, such as p15 (Figure 4A, 1), and Cyclin D1 (Figure 4A, 2), often deregulated in MDS and AML and associated with worse prognosis [7], [40], [41], [42], were modulated to a greater extent in HL60, whereas AXL (Figure 4A, 1), frequently up-regulated in AML and associated with adverse prognosis [30], was more marked in K562.