EIF2AK2 and Alzheimer disease: Activated PKR is increased in AD brains [10] and PKR activation via Aβ 1-42, can also lead to the phosphorylation of Tau protein and during oxidative stress can modify β –secretase 1 (BACE1) protein levels, one of the main enzyme implicated in the formation of Aβ peptides [10]–[12].