Compared to the control group, statistically significant increased risk of idiopathic spermatogenic impairment was found for carriers of rs10269148CG genotype of STRA8, when compared with homozygous carriers of the C allele in the infertility/abnormospermia group and azoospermia subgroup respectively [ORs and 95% CIs being 2.52 (1.29–4.94), 2.92 (1.41–6.06)], while in the oligozoospermia group, the frequency distribution showed no significant difference. The gene discussed is STRA8; the disease is Infertility.