It has been shown that histone deacetylase (H-DAC)-inhibitors such as butyrate, valproic acid (VPA) and trichostatin (TSA) and DNA methyltransferase (DNMT)- inhibitors such as decitabine, induce granulocytic maturation of t(8;21) acute myeloid leukemia cells [50], [51], [52], [53] (and data not shown). The gene discussed is DNMT1; the disease is acute myeloid leukemia.