An alternative explanation for the upregulation of SIRPα in t(8;21) AML was that these inhibitors of epigenetic silencing had acted directly on the SIRPα gene (accession number: NP-542970.1), and in fact this seemed possible since a prominent CpG island is present in the PTPNS1 promoter region. Here, SIRPA is linked to acute myeloid leukemia.