MBL2 and Sepsis: In contrast, septic patients with MBL depletion showed significantly higher sequential organ failure assessment (SOFA) scores, whereas functional MBL levels and activity in sepsis were associated with moderate SOFA scores and better prognosis [40], suggesting that MBL might be essential for defence against infections on the one hand, but might also harm the host and contribute to the development of MOF on the other hand.