Kawanishi et al. [8] also reported no weight loss or adipose tissue loss with a 5 d/wk, treadmill training protocol (60 min/d) following a 16-wk intervention, yet TNF-α and F4/80 gene expression were rescued by the training in their HF diet mice (60% HF diet) along with a decrease in CD11c (M1 macrophage marker). The gene discussed is TNF; the disease is hydrops fetalis.