In addition, founder mutations might exist in the Chinese population, such as the 1100delAT and 5589del8 mutations in BRCA116 and the 3109C>T mutation in BRCA2. 19 Among these, the 1100delAT mutations have also been identified in Malaysian Chinese,15 and the 5899del8 mutation has also been reported.11,13 Kwong et al19 found that the BRCA2 3109C>T mutation accounted for 28.6% of all BRCA2 mutations in a high-risk breast cancer group. The gene discussed is BRCA2; the disease is breast cancer.