BRCA2 and breast cancer: This is consistent with rates in other Asian ethnic groups.26 Moreover, in early-onset breast cancer, mutation rates of these genes were 5.1% and 4.0%, respectively.16 The overall BRCA1/BRCA2 mutation rate was 23.0% to 26.1% in both early-onset breast cancer and familial cases.16,23 A history of ovarian cancer was associated with a higher BRAC1/BRCA2 mutation rate in breast cancer, as compared with patients without such a history (26.7% vs 11.9%, P = 0.11).