The protein of the TP53 gene has important roles in the control of cell cycle progression, repair of DNA damage, genomic stability, and apoptosis.54TP53 mutations are found in 50% to 70% of individuals with Li-Fraumeni syndrome, an autosomal dominant inherited disease that was first reported in 1969 and is a rare cancer-predisposing syndrome. This evidence concerns the gene TP53 and Li-Fraumeni syndrome.