LMNA and Hutchinson-Gilford progeria syndrome: HGPS is caused by several mutations in the LMNA gene, the most common of which is the point mutation C1824T, which leads to the accumulation in the nuclear membrane of a rare splicing form of the Lamin-A called “progerin”, and alterations in nuclear shape and structure like the typical nuclear bubbling, the cytological hallmark of HGPS [8].