AKT2 and familial partial lipodystrophy, Dunnigan type: Among the five subtypes of FPL, Dunnigan syndrome (more than 300 patients) is most prevalent, followed by mutations in PPARγ (30 patients), PLIN1 (6 patients), AKT2 (four patients), and CIDEC (1 patient).126 Dunnigan syndrome is the most severe FPL, characterized by subcutaneous fat loss in both extremities and the trunk.