Interestingly, TLR7 appears to be a specific sensor for the induction of type I IFN production from plasmacytoid DCs, whereas TLR8 is specific for TNF-α production from monocytes in SLE patients, suggesting that plasmacytoid DCs and monocytes collaborate to develop inflammatory responses in SLE via distinct sensors. The gene discussed is TLR8; the disease is systemic lupus erythematosus.