Because the sera from SLE patients contains high levels of autoantibodies against self-antigens, such as small nuclear ribonucleoprotein particles (snRNPs) including ssRNA, TLR7, or TLR8 could recognize the immunocomplex of snRNPs with autoantibodies thorough Fc receptor-mediated internalization (Vollmer et al., 2005). The gene discussed is TLR7; the disease is systemic lupus erythematosus.