Intriguingly, although MyD88-deficient macrophages release much less cytokines than wild-type macrophages after staphylococcal infection, TLR2-deficient macrophages produce a significant amounts of cytokines, suggesting that other receptors associated with MyD88 are involved in Staphylococcus sensing (Takeuchi et al., 2000; Lembo et al., 2003). Here, MYD88 is linked to staphylococcal infection.