Thus, decreased expression of IL-8 receptors (CXCR-1 and CXCR-2) associated with enhanced chemoattractant production during sepsis may impair perception of chemoattractants by PMN and thereby contribute to defective PMN chemotaxis (Hayashi et al., 2003) (Figure 2). The gene discussed is CXCR2; the disease is Sepsis.