IL1R1 and Sepsis: Work with murine models of staphylococcal skin infections, arthritis and septicemia has led to the suggestion that IL-1R, that also signals through MyD88, is more important than TLR2 for neutrophil recruitment and bacterial clearance [(Hultgren et al., 2002; Verdrengh et al., 2004; Miller et al., 2006), reviewed in Sethi and Chakraborty (2011)].