SPHK1 and cancer: Whereas knockdown of SK1 reduces proliferation of, for example, glioblastoma cells (Van Brocklyn et al., 2005) and androgen-independent PC-3 prostate cancer cells (Akao et al., 2006), larger, more vascularized, resistant tumors are formed when cancer cells over-expressing SK1 are injected or implanted into mice (Pyne and Pyne, 2010).