SPHK1 and neoplasm: Thus, clinical prognostic outcome is linked with the combined high expression of nuclear SK1 and cytoplasmic phosphorylated c-RAF-1 or cytoplasmic phosphorylated AKT or nuclear ERK-1/2 expression or cytoplasmic Y416 phosphorylated SFK or LYN in the same tumor (Ohotski et al., 2012a).