Gu et al. [41] examined the circulating levels of cytokines in B-cell NHL (B-NHL), and reported that increased s-IL-2R and decreased IL-13 were significantly associated with the risk of B-NHL, and TNF-α, s-TNF-α and IL-5 were marginally associated with risk of B-NHL. This evidence concerns the gene TNF and B-cell non-Hodgkin lymphoma.