Interestingly, UAF1/WDR48 can fully activate the DUB activity of USP1, which regulates the Fanconi anemia DNA repair pathway [108], but only weakly stimulates the catalytic activity of USP46 and USP12 [105, 106, 108], whereas full activation of USP12 requires ternary complex formation with both UAF-1/WDR48 and WDR20 [106]. The gene discussed is WDR48; the disease is Fanconi anemia.