INS and type 2 diabetes mellitus: Glucocorticoid-induced diabetes is similar to type 2 diabetes because glucocorticoids impair glucose metabolism mainly through increasing insulin resistance, which occurs in the liver with increased basal glucose production, and in the adipose and skeletal tissues with impaired glucose utilization: to better understand the mechanisms of glucocorticoid-induced hyperglycaemia, Pagano et al. [55] evaluated the effect of prednisolone administration for 7 days in healthy volunteers, showing 50% reduction in insulin sensitivity by using insulin clamp methods.