In addition to these findings, other evidence to confirm the role of CNS in the genesis of hypertension has been revealed: a small dose of angiotensin II (Ang II) continuously administered subcutaneously (SC) gradually elevates BP, which can be abolished by intracerebroventricular (ICV) pretreatment with either an aldosterone synthase inhibitor or an MRB in rats [10]. Here, AGT is linked to hypertensive disorder.