Weidemann and colleagues recently demonstrated an association between increased fibrosis assessed by MRI and reduced longitudinal systolic function measured with tissue Doppler in AS.3 It is therefore intriguing that we observed reduced s′ velocities in patients with increased fibulin-1 levels, compatible with the idea that plasma fibulin-1 could reflect myocardial fibrosis. The gene discussed is FBLN1; the disease is Myocardial fibrosis.