C‐peptide levels (AUC=0.62) had significantly higher AUC's compared with fasting plasma glucose levels (AUC=0.56), HOMA‐IR index (AUC=0.58), fasting serum insulin levels (AUC=0.57), QUICKI index (AUC=0.42), and metabolic syndrome (AUC=0.56) for cardiovascular death, with P values at <0.001. This evidence concerns the gene INS and metabolic syndrome.