This hypothesis is further supported by recent studies on the association of GDF‐15 and coronary diseases as published by the Dallas Heart Study.44 Moreover, our findings and the data recently published27 on the functional proatherogenic role of GDF‐15 in lesion progression indicate that beside other TGF‐β superfamily members such as TGF‐β1 and BMP,45–46 interference with GDF‐15 may be a useful novel strategy for therapeutical intervention. This evidence concerns the gene TGFB1 and coronary artery disorder.