Survivors were evaluated for cardiac remodeling on day 28 post-MI.Echocardiographic examination revealed a markedly enlarged heart (LVEDD6.47±0.25 mm, n=16) with reduced LV systolic function (FS5.2±1.1%, n=16) in WT mice following MI (Figure 4B), whereas IL-17A-KO and IL-23-KOmice showed significantly less LV enlargement (LVEDD 5.64±0.21 mm,n=16, and 5.61±0.20 mm, n=9, respectively) and less severeLV dysfunction (FS 11.0±1.7%, n=16, and10.5±1.7%, n=9, respectively). This evidence concerns the gene IL17A and myocardial infarction.