VEGFA and diabetes mellitus: Impaired ischemic vascular remodeling during diabetes in Db/Db mice involves defective VEGF expression and signaling,27 with aged diabetic Db/Db mice manifesting severe defects in ischemic angiogenic responses.28,29 We next examined whether exogenous H2S therapy could augment ischemic limb reperfusion and vascular growth in 9‐month‐old, aged Db/Db mice subjected to femoral artery ligation.