BGN and metabolic syndrome: In the present study, we used the JCR:LA-cp rat model of MetS and IR to (1) determine the extent of arterial accumulation of intestinal-derived remnant lipoproteins ex vivo, (2) assess the effect of IR on the expression and properties of arterial biglycan to bind remnant lipoproteins, (3) understand the contribution of IR to altering remnant particle secretion and composition, and (4) determine the effect of ezetimibe and simvastatin on arterial accumulation of intestinal-derived remnant cholesterol ex vivo.