Several studies have found biglycan and decorin to colocalize with apoB in human atherosclerotic and restenotic lesions.28 Recently we have shown that intestinal-derived remnant lipoproteins also colocalize with arterial biglycan in an insulin-deficient model of type 1 diabetes mellitus ex vivo.12 McDonald et al29 also have reported that a high-fat–fed swine model of type 1 diabetes mellitus had a 4-fold increase in biglycan content in coronary artery lesions. This evidence concerns the gene INS and diabetes mellitus.