APOB and metabolic syndrome: Notably, native TRL-derived bound cholesterol was significantly higher for particles isolated during the fed state regardless of phenotype (4.32±1 versus 6.72±0.9 mg cholesterol per 1 mg apoB48 for lean rats in the fasted and fed states, respectively, P<0.05; 2.75±0.8 versus 14.8±0.9 mg cholesterol per 1 mg apoB48 for MetS rats in the fasted and fed states, respectively, P<0.01) (Figure 6).